In Vivo RNAi-Based Screens: Studies in Model Organisms
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چکیده
منابع مشابه
In Vivo RNAi-Based Screens: Studies in Model Organisms
RNA interference (RNAi) is a technique widely used for gene silencing in organisms and cultured cells, and depends on sequence homology between double-stranded RNA (dsRNA) and target mRNA molecules. Numerous cell-based genome-wide screens have successfully identified novel genes involved in various biological processes, including signal transduction, cell viability/death, and cell morphology. H...
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The strategies evolved by pathogens to infect hosts and the mechanisms used by the host to eliminate intruders are highly complex. Because several biological pathways and processes are conserved across model organisms, these organisms have been used for many years to elucidate and understand the mechanisms of the host-pathogen relationship and particularly to unravel the molecular processes ena...
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MOTIVATION Considerable attention has been directed in recent years toward the development of methods for the contextual analysis of expression data using interaction networks. Of particular interest has been the identification of active subnetworks by detecting regions enriched with differential expression. In contrast, however, very little effort has been made toward the application of compar...
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ژورنال
عنوان ژورنال: Genes
سال: 2013
ISSN: 2073-4425
DOI: 10.3390/genes4040646